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Nasel spray vaccines might stop the coronavirus in its tracks, although there’s little evidence from human trials so far.

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These mucosal vaccines target thin mucous membranes that line the nose, mouth and lungs. By prompting immune responses where SARS-CoV-2 first enters the body, mucosal vaccines could, in theory, prevent even mild cases of illness and block transmission to other people — something COVID-19 shots have been unable to do. Vaccines that produce sterilizing immunity would be game changing for the pandemic. ...

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Analysis: Study suggests new Omicron-specific vaccines offer only similar protection to existing boosters

In the coming days, people in the United States and the United Kingdom will be among the first to receive a new breed of COVID-19 vaccine. The hope was that these updated vaccines — based on Omicron variants of the SARS-CoV-2 virus — would offer substantially greater protection than older vaccines based on the strain of the virus that emerged in 2019.

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